Boonah Police are calling for witnesses after Boonah State High School was found with blue and black paint spread around the campus.
Police said a number of artworks which belonged to students were also destroyed.
The incident took place between 6pm on Friday and 11am on Sunday.
Police are asking anyone who may have observed someone in or around the school grounds during the time period to contact the Boonah station on 5463 3999.
Information can also be reported by contacting Policelink on 131 444 or providing information using the online form 24 hours per day.
You can also report information about crime anonymously to Crime Stoppers, a registered charity and community volunteer organisation, by calling 1800 333 000 or via crimestoppersqld.com.au 24 hours per day.